Does Canada have what it takes to grow domestic multinationals in knowledge-based industry sectors such as ICT, biotech and cleantech? What is the nature of Canada’s entrepreneurial culture? Are Canadian entrepreneurs able or willing to grow multinational firms? Does Canada have the executive talent to run tech multinationals from a Canadian base? Is such behaviour encouraged and recognized positively in Canada? Do we train our young people for these kinds of entrepreneurial and executive roles? Leading tech entrepreneurs and executives in Canada and the U.S. share their own experiences and perceptions on Canada’s entrepreneurial culture, and explore ways to improve Canada’s performance in knowledge-based commerce.